Great Lakes Regional Center of Excellence

Registration

Dr. Anthony Fauci, Director NIAID
Major Investments, Major Returns

Networking Session

Dinner Followed by Gallery Exhibits

Breakfast & Registration

Dr. Olaf Schneewind

Dr Christopher Walsh, Harvard
Antibiotics: Contemporary Challenges

Coffee Break

Breakout Session I

Jimmy Ballard, Novel therapeutic targets of Bacillus anthracis-host interactions
Arturo Casadevall, The Immunogenicity of Bacillus Anthracis Protective Antigen Domains and the Functional Efficacy of Elicited Antibody Responses Depend on host Genetic Background
James E. Galen, Cynomolgous primate studies with a Salmonella Typhi-based live vector anthrax vaccine
Tyler Nusca, Petrobactin Biosynthesis: A New Therapeutic Target Against Bacillus anthracis
Patrick Schlievert, B. anthracis and S. aureus Exotoxin Inhibition

Deborah Anderson, Therapeutic intervention of plague by monoclonal antibodies to LcrV
Richard Frothingham, Protective Role for G-CSF in Plague Infection
Jon Goguen, Reaction of Y. pestis to Atmospheric Oxygen Levels
Scott Minnich, Lipid A mimetics as adjuvants for a pneumonic plague vaccine
Olaf Schneewind, Yersinia pestis caf1 (F1) Variants and the Limits of Plague Vaccine Protection

Scott Balsitis, Tropism of dengue virus in mice and humans defined by viral NS3-specific immunohistochemistry
Robert Beatty, Developing a Fully Integrated Electromagnetic Sensor for Dengue Diagnosis
Shannon Bennett, Epidemic dynamics revealed in dengue sequence evolution
Adolfo Garcia-Sastre, Degradation of STAT2 by dengue virus

LeeAnn Blalock, Identification of Immunodominant Protein Antigens from Francisella tularensis by a Novel Screen Utilizing a High-throughput Immunoassay
Tina Guina, Role of the MglA-regulated surface protein Fsp53 in F. tularensis virulence and interaction with innate immunity
Daniel Hassett, Role of Antioxidant Enzymes, Glutathione, Fur and OxyR in Susceptibility to Oxidative Stress in Francisella tularensis.
Thomas Kawula, Promiscuity, Immune Suppression and Host Defense Evasion; Francisella tularensis Virulence Mechanisms at Play in Pulmonary Disease
Joseph Petrosino, Revealing the attenuation mutations of Francisella tularensis LVS and diagnostics to detect Francisella and Francisella infection

Stuart Isaacs, Development of a protein-based smallpox vaccine: Is there a future for future generation smallpox vaccines?
Earl Kern, In Vitro and In Vivo Activity of a New Series of Nucleoside Analogs Against Poxvirus Infections
Luzheng Liu, Skin scarification– An ancient vaccination strategy with unlimited promises in today and tomorrow
Robert Ricciardi, Use of High Throughput Screening to discover Pox and other Class A viral therapeutics
Richard Whitley, Drug Discovery for Orthopox Virus Infections

Christopher Basler, Ebola and Marburg viruses counteract interferon signaling by different mechanisms
Michael Buchmeier, Functional and Structural Proteomics of the SARS CoV: Modeling a Rational Response to Emerging Diseases.
Sue Delos, Characterizing a Minimal Receptor Binding site on the Ebola Virus Envelope Glycoprotein
Yoshihiro Kawaoka, Enigmas of emerging viral infections
Erich R. Mackow, Hantaviruses Direct Endothelial Cell Permeability by Sensitizing Cells to the Vascular Permeability Factor, VEGF, while Angiopoietin-1 and Sphingosine 1-Phosphate inhibit Hantavirus-directed Permeability

Joseph Barbieri, Vaccines against Botulism
Eric Johnson, Recombinant Holo-toxoid Vaccine Against Botulism
Markus Kalkum, Systemic detection of Botulinum Neurotoxin
Herman Staats, Mucosal targeting of nasally-administered vaccines augments induction of protective immunity to botulinum neurotoxin.

Lunch / Directors Lunch Meeting

Poster Session

Breakout Session II

Alan Cross, Induction of IL-1β by Bacillus anthracis spores and lethal toxin occurs through distinct signaling pathways with disparate functional consequences
Robert J Cybulski Jr, Superoxide Dismutases and the Bacillus anthracis spore
Philip C. Hanna, Spore Germination: Immediate Early Stage of Anthrax
Erik Hewlett, Differential Potencies of B. anthracis Edema Toxin related to N-terminal Histidine Tag

Luis Quadri, Biosynthesis and Inhibition of "Small-Molecule" Virulence Factors: Novel Routes to Anti-Infectives
Richard Slayden, Development of Novel Chemotherapeutics Against Priority Pathogens
Ann Thanawastien, Immune Responses Induced by Protein Capsular Matrix Vaccines (PCMVs)
Michael Vasil, Identification of of the Twin-Arginine- Translocase (TAT) Inhibitors

R. Bruce Cary, Toward Lateral Flow Chromatographic Lab-On-a-Chip Diagnostics
Joshua LaBaer, Proteomics strategies for vaccine and target discovery
James Mecham, Development of Surface Enhanced Raman Scattering (SERS) Assays for West Nile Virus

Debasish Chattopadhyay, Structural Investigation of Poxvirus Replication
David Pickup, Poxviral subversion of dendritic cell functions.
Matthew Wiebe, BAF: An Intrinsic Host Defense Responsive to Foreign DNA

Robert Davey, Drugs used to treat hypertension are effective inhibitors of Ebola virus infection and may provide a way to treat disease.
David Knipe, HSV Recombinants as Biodefense Vaccine Vectors and Probes of Innate Immunity
Nito Panganiban, Screening for Molecules That Interfere with Hantavirus Nucleocapsid Protein

Shinji Makino, Rift Valley fever virus NSs protein induces PKR degradation and promotes virus replication under host transcriptional suppression
Nang Nguyen, Seroepidemiology of the Newly Discovered WU Polyomavirus
Jack Nunberg, Arenavirus Entry and its Inhibition
Katherine Ryman, Evasion of Type I IFN Induction as a Mechanism of Eastern Equine Encephalitis Virus Virulence

Anne-Sophie Brocard, The Need and Availability for a Biosafety Training Program among the RCE community
Harold "Skip" Garner, Services and Status of the WRCE Computational Core
Douglas Watts, Is Biodefense Research Regulation Protecting Public Health and National Security?

Coffee Break

Breakout Session III

Josephine Chandler, A new PheS counterselectable marker system for generation of unmarked mutations in the Burkholderia mallei-pseudomallei-thailandensis group: construction of quorum sensing signal generation and signal reception mutants
Philip Felgner, Anti-Burkholderia pseudomallei humoral immunity profiles from melioidosis patients and healthy individuals from Thailand, Singapore and USA
Hillary Hayden, Structural variation in Burkholderia pseudomallei using comparative genome analysis
Andres Vazquez-Torres, Inactivation of [Fe-S] metalloproteins mediates nitric oxide-dependent killing of Burkholderia mallei
Martin Voskuil, Metabolism and phenotypic drug tolerance of anaerobic Burkholderia pseudomallei
David Wagner, Burkholderia pseudomallei strains that infect animals are a distinct subset of strains found in the environment

Dean Crick, IspE – Substrate synthesis, characterization and development of a high through-put screen.
Kevin Mayo, Designed Cationic Peptides and Mimetics as Broad Spectrum Bactericidal Agents
Ning Pan, Discovery and development of small molecule inhibitors targeting type III secretion in Yersinia pestis
Bruno Sobral, Identification of Targets for Counter Measures Using Computational Methods and Biological Validation Using High-Throughput Data
Peter Tonge, Broad Spectrum Antimicrobial Agents That Target fatty Acid Biosynthesis

Allen Harmsen, Immunopathogenesis of Coxiella Pneumonia
Chuan He, Regulation of Virulence and Antibiotic Resistance in Pathogens
Juan Martinez, More from the rOmp(er) room: Elucidating critical interactions involved in the infection of mammalian cells by spotted fever group rickettsiae
Michael Minnick, The sole 23S rRNA gene of Coxiella burnetii encodes two group I introns (ribozymes) that potentially affect growth and development
Craig Morita, Unique features of Vγ2Vδ2 T cell memory provides for bridge immunity to infections
Renee Tsolis, Profiling the humoral response to Brucella melitensis infection using proteome microarrays: comparison of immunodominant antigens in natural and incidental hosts

Bradley Britigan, Gallium Disrupts Francisella Iron Uptake and Shows Therapeutic Efficacy in a Murine Model of Pulmonary Francisella Infection
Robert Ernst, Francisella mutants in lipid A biosynthesis protect against wild type Francisella challenge in an MyD88-dependent manner
Taehyun Kim, Functional characterization of O-antigen polymerase in Francisella tularensis Live Vaccine Strain.
Barbara Mann, Immunization with an attenuated Schu S4 mutant in a dsbA-like gene protects against wild-type challenge.
Larry Schlesinger, Lung Innate Immune Responses to Francisella Tularensis: a Central Role for the Macrophage
Thomas Zahrt, Comparison of LVS ΔpurMCD and Schu S4 ΔpurMCD auxotrophs as live vaccine candidates for Francisella tularensis

Carol Blair, Human and humanized monoclonal antibodies with prophylactic and therapeutic potential for arbovirus infections
John Connor, Inhibitors of Hsp90 as antiviral agents
Robert Silverman, Small-Molecule Activators of RNase L with Broad-Spectrum Antiviral Activity
Kathryn Sykes, Molecular Technologies Toward Better Vaccines for Emerging and Biothreat Agents
Sean Whelan, Polymerases of negative-strand RNA viruses.

Sara Cherry, Identification of Host Factors Involved in Viral Replication of Emerging Pathogens Using Genome-wide RNAi Screening
Gary Cohen, Vaccinia Virus L1 binds to cell surfaces and blocks virus infection independently of glycosaminoglycans
Daved Fremont, Structural mechanisms of viral immune evasion
Mike Holbrook, Characterization of Omsk hemorrhagic fever virus infection in the mouse model
David Miller, Innate Immunity and Neurotropic Arbovirus Pathogenesis
Christiane Wobus, Mechanisms of murine norovirus entry

Breakfast

Dr. Rona Hirschberg
An Interim Evaluation of the RCE Program

Dr Bernard Roizman
Herpes simplex virus (HSV) vs. the host cell: Tales of bioterrorism, mayhem, and self sacrifice.

Coffee Break

Breakout Session IV

Molly Hughes, Direct Effects of Host Chemokines on Bacillus anthracis
Andrzej Joachimiak, The Crystal Structure of Capsule Synthesis Protein CapD, a Major Virulence Factor in Bacillus anthracis
Dominique Missiakas, Inhibition of capsule assembly in the envelope of Bacillus anthracis
Carol Sabourin, Animal Models for Inhalation Anthrax
Alfred Tamayo, Translocation of Anthrax Toxin LFnDTA from Endocytic Vesicles is Facilitated by a COPI Protein Complex in vitro

James Crowe, Neutralizing Monoclonal Antibodies derived from B-cells of 1918 Influenza pandemic survivors
Donald Jarvis, Producing Influenza Virus Subunit Vaccines in the Baculovirus-Insect Cell System
Sarah Kopecky-Bromberg, The adjuvant alpha-C-galactosylceramide enhances protection of a live attenuated influenza virus vaccine
Ming Luo, Fusion inhibitors of influenza virus
Andrew Rice, Characterization of Novel Cellular Targets of Avian Influenza NS1 Protein and Implications for Pathogenesis

Brian Geiss, Development and Optimization of Novel Anti-Flavivirus Compounds
Kyle Johnson, Nodavirus-based RNA Replicon Vaccines for Tick-borne Encephalitis Virus
Richard Kuhn, Development of Antiviral Compounds Against Flaviviruses
Kenneth Olson, Evaluation of Cationic Lipid DNA Complex (CLDC) in small animal models as a platform for both therapeutic treatment and vaccine development for alphavirus infections
Scott Weaver, IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells

Eileen Barry, Development of Live Attenuated Shigella dysenteriae Vaccine Strains
Thomas Ficht, Microencapsulation and Controlled Release of Attenuated Live Vaccines
David Haslam, Small molecule inhibition reveals differing roles for Arf1 guanine exchange factors in intracellular toxin transport.
Tom Obrig, Anti-Chemokine Antibodies: A Therapy for Shiga Toxin-Associated HUS
Gary Splitter, Development of a Human Vaccine Against Brucella

Gregory Buck, Innate and adaptive protective immune responses against recombinant Cryptosporidium antigens
Richard Guerrant, Novel Anti-cryptosporidial Interventions
Mark Jutila, Targeting the innate immune system in Phase I Coxiella burnetii infection.
Kami Kim, A Systems Biology Approach to Differentiation of Toxoplasma gondii
Mark Wurfel, Effect of the TLR4 Asp299Gly polymorphism differs between lipopolysaccharides of differing acyl chain structure.

Mady Hornig, Neuroendocrine augmentation of antiviral responses in aged mouse and nonhuman primate models of West Nile virus (WNV) NY99
Robyn Klein, Chemokines shape antiviral immune responses during West Nile virus encephalitis
John D. Morrey, Electrical nerve conduction deficits in acute West Nile virus encephalitis and in subsequent neurological sequelae

Closing remarks and Lunch

Administrators Lunch Meeting